Issue 177

Is connection key? How clinicians impact patient outcomes in psychedelic therapy

A wealth of research is showing how psychedelic-assisted therapy holds promise for the treatment of mental health conditions such as depression, but what role does the therapist play in a patient’s outcome? A new study has suggested it may be a big one.

Psychedelics have piqued huge interest due to their effects on the brain. Research points to their ability to induce neuroplasticity in the brain as one of the key reasons they may help with conditions such as depression and anxiety.

However, set – the individual’s (or patient’s) mental state – and setting – the individual’s environment during a psychedelic experience – are hugely impactful on the outcome of these experiences.

In the traditional use of psychedelic medicines, shamans help to guide set and setting throughout the experience with singing, drumming and ritual. Today, in scientific research, trials, and in clinics, the clinician is essentially playing this role.

To find out more about the impact of the “therapeutic alliance” in psychedelic therapy, researchers from Ohio State University College of Medicine analysed data from a clinical trial that investigated psilocybin-assisted psychotherapy for the treatment of major depressive disorder (MDD), finding that a stronger relationship between patient and clinician led to a better clinical outcome for the patient – with improved depression scores up to 12 months following the experience.

READ MORE

HOW TO UNTANGLE ETHICS OF PSYCHEDELICS FOR THERAPEUTIC CARE

For the Harvard Gazette, experts from law, philosophy, and spiritual care discuss issues surrounding the research and safer use of psychedelics, kicking off the “Divinity School initiative”.

“Psychedelic experiences don’t match to psychedelic substances, in not only that the same dose of the same substance doesn’t induce the same effects in different people, or even in the same person twice.” Christine Hauskeller.

Read More

IT IS HIGH TIME THE UK CHANGES PSYCHEDELICS LAWS

In the Regulatory Review, Joanna Neill, Psychopharmacology Professor at the University of Manchester, suggests that the government should lower regulatory hurdles impeding psychedelic research.

“The wheels of change are turning around the world, albeit slowly—creating a risk that the United Kingdom will be left behind as other countries forge ahead with more evidence-based drug laws,” writes Professor Neill.

Read More

SCIENCE AND RESEARCH

A new study has developed an approach to better understand how psychedelics affect the brain using zebrafish.

Big Think explores how exposure to visual stimuli can diminish the effects of psychedelic drugs.

REGULATION AND LEGISLATION

WBUR looks at how psychedelics are on a path that could lead them to become an integral part of mental health care in Massachusetts.

In an essay for The Regulatory Review, Victoria Litman posits that psychedelic dispensaries should be part of the conversation on psychedelic therapy.

BUSINESS AND INVESTMENT

SynBioBeta looks at how precision fermentation allows companies to produce a range of psychedelics and derivatives at scale.

atai Life Sciences has announced the dosing of the first patient in Part 2 of Beckley Psytech’s Phase 2a study of BPL-003 and SSRIs in patients with Treatment Resistant Depression.

Kellog Insight explores how the industry will grow as psychedelic-assisted therapy goes mainstream.

Cybin has published its research manuscript exploring the structure-activity relationships of a broad range of 2C-X analogues in the Journal of Medicinal Chemistry.

ARTICLES OF INTEREST

The UK Prime Minister’s recent comments about mental health and work are not based on robust evidence and could lead to policies and practices that do more harm than good, the Centre for Mental Health has warned.

A new Health Foundation report has shown that the UK’s poor health epidemic could negatively impact the economy – with anxiety and depression projected to increase in the 10% most deprived areas by 2040.